Blood is a fluid connective tissue that circulate continuously around the body, allowing constant communication between tissues distant from each other. Mar 17, 2018 for the love of physics walter lewin may 16, 2011 duration. The plasma expanders most widely used are isotonic crystalloids and synthetic colloids. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that todays audiences expect. Beta agonists bind to receptors on the cell surface that are coupled to the intracellular enzyme adenylate cyclase via the stimulatory transmembrane gtpbinding protein. The complex composition of these colloidal agents broad range of molecular weight distribution in vitro and in vivo confounds their. It is an important determinant in the appearance of edema normally 24 mm hg interstitial fluid exerts hydrostatic. In the mid 1980s, largevolume paracentesis was reintroduced without plasma expanders and was once again deemed a safe practice that would not cause a change in plasma volume. A clear, straw coloured, watery fluid in which several different types of blood cells are suspended. Drugs which decrease fibrin formation anticoagulants these are the drugs which act. It is not heavily referenced, but important key papers are cited as further.
Questions for the third and fourth exams will be taken from the powerpoint presentations. Mbbs made easy second mbbs examination pharmacology. Bioassay bioassay is the estimation of potency of an active principle i. The currently available colloids vary in their physicochemical, pharmacodynamic and pharmacokinetic properties. Blood and plasma volume expanders linkedin slideshare. The currently available colloids vary in their physicochemical, pharmacodynamics and pharmacokinetic properties. Diagrams representing the process and the study prove a best way to explain theories related to the branch as well as in elaborating on health care, prescription drugs, and. Plasma expanders based on starch or dextran had no effect on the renal uptake of 111 inoctreotide. We recommend printing this in a lettersized paper 8. Whether youve loved the book or not, if you give your honest and detailed thoughts then people will find new books that are right for them.
Other readers will always be interested in your opinion of the books youve read. View and download powerpoint presentations on atracurium ppt. Gelatinbased plasma expander effectively reduces renal. Fibrinolytic drugs and plasma expanders briefly youtube. Pharmacology for anaesthesiologists british journal of. Introduction to general principles of pharmacology authorstream presentation. Mechanism of action of dextran dextran is a plasma volume expander which reduces blood viscosity. You can manage this and all other alerts in my account.
Drugs acting on blood coagulation system and their. Anemia decreases oxygencarrying capacity and blood viscosity. All the available plasma volume expanders may rarely induce anaphylactoid reactions, although such reactions are extremely uncommon in shocked patients. Ppt chapter 28 agents used in blood and hematopoietic. Plasma expanders are agents that have relatively high molecular weight and boost the plasma volume by increasing the osmotic pressure. Critical levels of oxygen delivery in otherwise fit, resting adults occur at about 5 gdl. Download the book into available format new update. It is prepared from human plasma and is available as a concentrate containing 1525% total protein, pharmacology of plasma expanders barbara j pleuvry barbara j pleuvry is senior lecturer in anaesthesia and pharmacology at the university of manchester, uk. It is an intravenous colloid that behaves much like blood filled with albumins. These drugs are plasma expanders which lead to decrease in the vascular stasis, there by decrease platelet adhesiveness 8086. This may be a very good tool to teach the students about plasma expander. The effect of various plasma expanders on blood coagulation was studied using the thromboelastography teg.
Pharmacology of drugs acting on blood and blood forming agents a anticoagulants b thrombolytics and antiplatelet agents c haemopoietics and plasma expanders 2. Plasma proteins exert constant osmotic pressure colloid oncotic pressure a form of osmotic pressure exerted by proteins in a blood vessels plasma bloodliquid that pull water into the circulatory system. Plasma volume expanders are used in connection to paracentesis in people with cirrhosis to prevent reduction of effective plasma. Catecholamines eg, norepinephrine, epinephrine, and dobutamine with beta agonist activity regulate intramyocyte calcium levels via the nucleotide cyclic adenosine monophosphate cyclic amp. Use the pharmacology powerpoint presentations as a resource for your brochure project. Ppt plasma membrane physiology structure and role in.
Find powerpoint presentations and slides using the power of, find free presentations research about atracurium ppt. Gelofusine is a colloid volume expander which may be used as a blood plasma replacement when a significant amount of blood is lost due to extreme hemorrhagia, trauma, dehydration, or a similar event. Pdf plasma expanders used to treat or prevent hypotension can. Clinical pharmacology associated with cardiac surgery is an important part of patient management. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. Fluids and electrolytes crystalloids volume expander fluids that supply water and sodium help to maintain osmotic gradient between extravascular and intravascular compartments plasma volume expanders due to sodium concentrations do not contain proteins colloids contain fluids and electrolytes that are normally found in the body better for treating dehydration rather. Clinical pharmacokinetic considerations in the use of plasma expanders. An experimental study on the effect of plasma expanders on. Pharmacology may be defined as the study of effect of a drug chemical on the body living system it includes, history, source, physical and chemical properties, compounding, biochemical and physiological effects, pk and pd, therapeutic and other uses, precautions, adverse effects, interactions and contraindications of drugs. Blood is a fluid connective tissue that circulates continuosly around the body,allowing constant communication between tissues distant from each other.
All plasma expanders exert metabolic effects either favorable effects such as correction of hypovolemiainduced lactic acidosis or renal failure, or unwanted adverse effects such as hypotonic. Ppt antimicrobial drugs powerpoint presentation free. The complex composition of these colloidal agents broad range of molecular weight distribution in vitro and in vivo, confounds their specific assay and meaningful pharmacokinetic analysis. Plasma expanders are used to restore the circulating volume of a hypovolaemic patient.
Listed below is a table which may serve as your quick reference guide on the different intravenous solutions. Plasma and blood volume expanders medicine libretexts. Jun 28, 2017 the practitioner may prescribe a colloid plasma expander if your patients blood volume doesnt improve with crystalloids. Hextend is administered by intravenous infusion only. If possible, vasopressors should not be given, but if a vasopressor is required, care should be taken not to precipitate or aggravate cardiac arrhythmia. They can serve as additional source of information for study of pharmacology and clinical pharmacology. This is an excellent text covering current basic pharmacology for anaesthetists that will be welcomed by those studying for the primary frca and by those teaching them. Antimicrobial drugs kharkov national medical university department of pharmacology and medical prescription assistant gordiychuk d. It intends to grow day by day, contributions from readers is highly appreciated. Present studies show that correcting the decrease of blood viscosity by increasing plasma viscosity with newly developed plasma expanders significantly improves tissue perfusion. Because gelofusine is a wellknown and generally used blood volume substitute that can be applied. In addition, the timedependent decline of plasma concentrations of the plasma. Winner of the standing ovation award for best powerpoint templates from presentations magazine.
Pharmacology of plasma expanders pdf free download. Lecture presentations pptpdf in this section you can find sylabes slides from powerpoint presentations from selected lectures and seminars. Pharmacology of plasma expanders postoperative care. Please help improve this section by adding citations to reliable. Learn pharmacology ppt 1 with free interactive flashcards. Pdf on sep 1, 1998, s r walker and others published plasma expanders used to treat or prevent hypotension can themselves cause hypotension find, read. Lecture 1 lecture 2 lecture 3 lecture 4 lecture 5 lecture 6 lecture 7 lecture 8 lecture 9 lecture 10 lecture 11. Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience. A volume expander is a type of intravenous therapy that has the function of providing volume for the circulatory system. Plasma expanders are hyperoncotic andor hypertonic fluids that expand the circulating blood volume more than isotoniciso oncotic fluids. Typically, colloids are used to expand the plasma volume, although combinations of hypertonic crystalloid and colloid have recently been used.
This is the list of the pharmacology powerpoint presentations available at pharmacology corner. Clinical pharmacokinetic considerations in the use of. Adverse reactions to plasma volume expanders springerlink. Pharmacology is the study of interaction of drugs with living organisms. View pharmacokinetics ppts online, safely and virusfree. Sir i am unable to download this ppt from hear, please send me a copy of this presentation. Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects. Plasma expander definition of plasma expander by medical. Clinical pharmacy and practical drug safety from in a to z. These new plasma expanders promote tissue perfusion, increasing oxygen delivery capacity without increasing blood oxygencarrying capacity, thus. Blood and plasma volume expanderspharmacology medical.
Hypolipidaemic drugs and plasma expanders 634 section 11. Clinical pharmacokinetic considerations in the use of plasma. Chemotherapy a introduction b sulfonamides and cotrimoxazole c penicillins and. The reactions are caused by different mechanisms depending on the solution, and there is little evidence that ige antibodies are involved. Blood and plasma volume expanderspharmacology free download as powerpoint presentation. The gelatinbased plasma expander gelofusine significantly reduced the kidney uptake of 111 inoctreotide as effectively as did lysine.
Pharmacology powerpoints cme at pharmacology corner. Blood and plasma volume expanders pharmacology free download as powerpoint presentation. Patients in the perioperative period receive multiple agents that affect cardiovascular and pulmonary function. Shock occurs due to reduced blood volume usually due to hemorrhage and it is necessary to get the blood volume back to normal as quickly. They are used to treat patients who have suffered hemorrhage or shock. View and download powerpoint presentations on plasma expanders ppt. Pharmacology 120 julie cordts instructor pharmacology powerpoint lectures all lessons will open in a new browser window allowing easy access to this menu. A volume expander is a type of intravenous therapy that provides fluid replacement for the circulatory system. Alka bansal associate professor, department of pharmacology, sms medical college, jaipur.
Pharmacology of drugs acting on renal system a diuretics b antidiuretics 3. Introduction to general principles of pharmacology. Pharmacology of drugs acting on cardio vascular system. Solutions of 5, 10, 20, and 50% concentration of each expander 6% low molecular weight hydroxyethylstarch 6% hespander, 3% dextran40, 6% high molecular weight hydroxyethylstarch 6 hes, and 6% dextran70 or solvent lactated. Total dosage and rate of infusion depend upon the amount of blood or plasma lost and the resultant hemoconcentration as well as age, weight, and clinical condition of the patient. Dextran about dextran a group of longchain polysaccharides composed of glucose,intravenous fluids, plasma expanders substitutes for whole blood in severe shock. Find powerpoint presentations and slides using the power of, find free presentations research about plasma expanders ppt. Plasma volume expanders are effective in the restoration of blood volume. Digitalization may be necessary, and renal function should be monitored and supported as required. Choose from 500 different sets of pharmacology ppt 1 flashcards on quizlet. A free powerpoint ppt presentation displayed as a flash slide show on id. There are plenty of tables and diagrams that are well designed and clearly presented. Understand drug safety and effectiveness like factors affecting drug action and adverse drug reactions. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext.
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